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Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes.
M Tominaga, A Matsumori, M Horie, H Yoshida, Y Okada
M Tominaga, A Matsumori, M Horie, H Yoshida, Y Okada
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Research Article

Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes.

Abstract

The pathogenesis of myocarditis and dilated cardiomyopathy is though to involve autoimmunological processes and myocardial calcium overload. Serum containing antiheart antibodies associated with a murine model of myocarditis increased [Ca2+]i in guinea pig ventricular myocytes only in the presence of extracellular Ca2+. The antiheart antibody-positive serum activated Ca(2+)-permeable cation channels that were insensitive to dihydropyridines and membrane stretch. The permeability sequence was Ba2+ > Ca2+ > Na+ approximately K+, and the single-channel conductance to Ba2+ was 12 pS. The channel was activated by extracellular application of the serum during on-cell recording, which suggests that a soluble intracellular messenger may be involved. The antibody-positive serum did not alter voltage-gated Ca2+ currents. We propose that excess Ca entry in myocarditis and dilated cardiomyopathy results from activation of a Ca(2+)-permeable cationic channel by the autoantibodies.

Authors

M Tominaga, A Matsumori, M Horie, H Yoshida, Y Okada

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