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Usage Information

Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica.
L L Braga, … , P J Sims, W A Petri Jr
L L Braga, … , P J Sims, W A Petri Jr
Published September 1, 1992
Citation Information: J Clin Invest. 1992;90(3):1131-1137. https://doi.org/10.1172/JCI115931.
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Research Article

Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica.

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Abstract

The human complement system is an important early host defense against infection. Entamoeba histolytica activates the complement system but is resistant to killing by complement C5b-9 complexes deposited on the membrane surface. Our aim was to identify components of the amebic plasma membrane that mediate resistance to human complement C5b-9 by screening for neutralizing monoclonal antibodies. A monoclonal antibody was identified that abrogated amebic resistance to C5b-9, and the mAb was shown to recognize the parasite's galactose-specific adhesin. The purified adhesin bound to C8 and C9 and conferred C5b-9 resistance to sensitive ameba upon reconstitution; these activities of the adhesin were inhibited by the antiadhesin mAb. The E. histolytica adhesin shared sequence similarities and antigenic cross-reactivity with CD59, a membrane inhibitor of C5b-9 in human blood cells, suggesting both molecular mimicry and shared complement-inhibitory functions.

Authors

L L Braga, H Ninomiya, J J McCoy, S Eacker, T Wiedmer, C Pham, S Wood, P J Sims, W A Petri Jr

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