Advertisement

Amendment history:

Research Article Free access | 10.1172/JCI115635

T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients.

T Sumida, F Yonaha, T Maeda, E Tanabe, T Koike, H Tomioka, and S Yoshida

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Sumida, T. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Yonaha, F. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Maeda, T. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Tanabe, E. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Koike, T. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Tomioka, H. in: JCI | PubMed | Google Scholar

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

Find articles by Yoshida, S. in: JCI | PubMed | Google Scholar

Published February 1, 1992 - More info

Published in Volume 89, Issue 2 on February 1, 1992
J Clin Invest. 1992;89(2):681–685. https://doi.org/10.1172/JCI115635.
© 1992 The American Society for Clinical Investigation
Published February 1, 1992 - Version history
View PDF
Abstract

Infiltrating T cells around salivary glands in the lips of Sjögren's syndrome (SjS) patients are crucial in the pathogenesis of this disease. To analyze the nature of infiltrating T cells, their T cell receptor repertoire was examined with quantitative polymerase chain reaction. The repertoire of V beta transcripts in lips of SjS was not restricted; however, the V beta 2 and V beta 13 genes were predominantly expressed on the T cells of lip specimens in six and four of seven lips, respectively. Predominance of these genes was specific in lips because no predominant V beta transcripts were found in lips from healthy subjects and PBLs from SjS patients. These results indicated that the V beta 2- and V beta 13-positive T cells expanded specifically and preferentially in SjS lips, thereby suggesting the possible role in triggering the autoimmunity of this disease.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (February 1, 1992): No description
Advertisement
Advertisement