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Research Article Free access | 10.1172/JCI115552

Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemia-reperfusion.

K Fujimoto, I Imamura, D N Granger, H Wada, T Sakata, and P Tso

Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

Find articles by Fujimoto, K. in: JCI | PubMed | Google Scholar

Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

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Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

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Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

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Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

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Department of Physiology, Louisiana State University Medical Center, Shreveport 71130.

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Published January 1, 1992 - More info

Published in Volume 89, Issue 1 on January 1, 1992
J Clin Invest. 1992;89(1):126–133. https://doi.org/10.1172/JCI115552.
© 1992 The American Society for Clinical Investigation
Published January 1, 1992 - Version history
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Abstract

The aim of this experiment was to demonstrate whether histamine and histidine decarboxylase (HDC) contribute to mucosal repair in small intestine subjected to ischemia-reperfusion (I/R). The superior mesenteric artery was occluded for 15 min followed by reperfusion. In jejunal mucosa, histamine content and HDC activity increased after I/R. Histamine output in mesenteric lymph was also elevated after I/R. These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. alpha-FMH also attenuated the increase of ornithine decarboxylase (ODC) activity normally observed after I/R. Transport of dietary lipid into lymph markedly decreased at 24 h after I/R, yet it was restored to normal at 48 h after I/R. alpha-FMH inhibitor led to a sustained deficit in lipid transport at 48 h after I/R. This sustained functional impairment in alpha-FMH treated animals was associated with blunted responses of HDC activity and histamine content to I/R. Our results suggest that histamine and HDC contribute to the restoration in mucosal function observed at 48 h after I/R. This response may be related, at least in part, to stimulation of ODC activity by histamine.

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