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Research Article Free access | 10.1172/JCI115170

Clonal analysis of CD4+/CD8+ T cells in a patient with aplastic anemia.

U Moebius, F Herrmann, T Hercend, and S C Meuer

Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG.

Find articles by Moebius, U. in: PubMed | Google Scholar

Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG.

Find articles by Herrmann, F. in: PubMed | Google Scholar

Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG.

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Abteilung Angewandte Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG.

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Published May 1, 1991 - More info

Published in Volume 87, Issue 5 on May 1, 1991
J Clin Invest. 1991;87(5):1567–1574. https://doi.org/10.1172/JCI115170.
© 1991 The American Society for Clinical Investigation
Published May 1, 1991 - Version history
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Abstract

T cell clones were established from peripheral blood of a patient with severe aplastic anemia. 8 of 18 individual clonal T cell populations stably coexpressed CD4 and CD8 molecules, a phenotype characteristic for thymocytes and a minor subpopulation of circulating T lymphocytes. Analysis of T cell receptor genes revealed identical rearrangements of T cell receptor beta chain genes, suggesting clonality of these T cells. CD4+/CD8+ T cells clones were found to be efficiently cytotoxic towards autologous lymphoblasts. Autocytotoxicity could be blocked by a CD3 MAb, a MAb specific for monomorphic MHC class II determinants, and particularly, by an MHC-DP-specific MAb, suggesting specificity for autologous DP molecules. Perhaps more important, CD4+/CD8+ T cell clones inhibited differentiation of autologous progenitor enriched bone marrow cells in vitro by a direct cell-mediated mechanism. These data suggest that circulating cytotoxic CD4+/CD8+ T cell clones specific for autologous MHC-DP determinants may be involved in hematopoietic failure in some cases of aplastic anemia.

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