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Research Article Free access | 10.1172/JCI115100

Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration.

S R Myers, O P McGuinness, D W Neal, and A D Cherrington

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615.

Find articles by Myers, S. in: PubMed | Google Scholar

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615.

Find articles by McGuinness, O. in: PubMed | Google Scholar

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615.

Find articles by Neal, D. in: PubMed | Google Scholar

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615.

Find articles by Cherrington, A. in: PubMed | Google Scholar

Published March 1, 1991 - More info

Published in Volume 87, Issue 3 on March 1, 1991
J Clin Invest. 1991;87(3):930–939. https://doi.org/10.1172/JCI115100.
© 1991 The American Society for Clinical Investigation
Published March 1, 1991 - Version history
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Abstract

To examine the relationship between net hepatic glucose uptake (NHGU) and the insulin level and to determine the effects of portal glucose delivery on that relationship, NHGU was evaluated at three different insulin levels in seven 42-h-fasted, conscious dogs during peripheral glucose delivery and during a combination of peripheral and portal glucose delivery. During peripheral glucose delivery, at arterial blood glucose levels of approximately 175 mg/dl and insulin levels reaching the liver of 51 +/- 2, 92 +/- 6, and 191 +/- 6 microU/ml, respectively, NHGUs were 0.55 +/- 0.30, 1.52 +/- 0.44, and 3.04 +/- 0.79 mg/kg per min, respectively. At hepatic glucose loads comparable to those achieved during peripheral glucose delivery and inflowing insulin levels of 50 +/- 4, 96 +/- 5, and 170 +/- 8 microU per ml, respectively, NHGUs were 1.96 +/- 0.48, 3.67 +/- 0.68, and 5.52 +/- 0.92 mg/kg per min when a portion of the glucose load was delivered directly into the portal vein. The results of these studies thus indicate that net hepatic glucose uptake is dependent on both the plasma insulin level and the route of glucose delivery and that under physiological conditions the "portal" signal is at least as important as insulin in the determination of net hepatic glucose uptake.

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