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Research Article Free access | 10.1172/JCI115088

Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype.

A Grayzel, A Solomon, C Aranow, and B Diamond

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

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Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

Find articles by Solomon, A. in: PubMed | Google Scholar

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

Find articles by Aranow, C. in: PubMed | Google Scholar

Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.

Find articles by Diamond, B. in: PubMed | Google Scholar

Published March 1, 1991 - More info

Published in Volume 87, Issue 3 on March 1, 1991
J Clin Invest. 1991;87(3):842–846. https://doi.org/10.1172/JCI115088.
© 1991 The American Society for Clinical Investigation
Published March 1, 1991 - Version history
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Abstract

There is evidence in both murine and human lupus that the production of anti-DNA antibodies may be triggered by environmental antigens. To explore this further, we studied the serum of 10 nonautoimmune individuals immunized with a polyvalent pneumococcal polysaccharide vaccine. All 10 patients showed a rise in the titer of antipneumococcal antibodies bearing an anti-DNA-associated idiotype. The antipneumococcal response was specific as no idiotypic antitetanus antibodies were detected. Furthermore, no anti-DNA antibodies were present in postvaccination sera. The molecular analysis of antipneumococcal and anti-DNA antibodies bearing a common idiotype will help elucidate how foreign antigen might lead to the production of anti-DNA antibodies in susceptible individuals.

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