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Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.
K J Tracey, S Morgello, B Koplin, T J Fahey 3rd, J Fox, A Aledo, K R Manogue, and A Cerami
Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Laboratory of Medical Biochemistry, Rockefeller University, New York, New York.
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Published December 1, 1990 - More info
J Clin Invest. 1990;86(6):2014–2024. https://doi.org/10.1172/JCI114937.
© 1990 The American Society for Clinical Investigation
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)