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Research Article Free access | 10.1172/JCI114678

Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes.

D Emilie, M Peuchmaur, M C Maillot, M C Crevon, N Brousse, J F Delfraissy, J Dormont, and P Galanaud

Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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Institut National de la Santé et de la Recherche Médicale U131, Hôpital A Béclère, Clamart, France.

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First published July 1, 1990 - More info

Published in Volume 86, Issue 1 on July 1, 1990
J Clin Invest. 1990;86(1):148–159. https://doi.org/10.1172/JCI114678.
© 1990 The American Society for Clinical Investigation
First published July 1, 1990 - Version history
Abstract

To document the in vivo interactions occurring between the immune system and HIV replicating cells, we analyzed using in situ hybridization the production of IL-1 beta, IL-6, IL-2, and INF-gamma in eight hyperplastic lymph nodes from HIV-1 infected patients. Numerous IL-1 beta- and IL-6-producing cells associated in clusters were detected in sinuses. Few individual IL-1 beta- and IL-6-producing cells were present in interfollicular and follicular areas. IL-2- and INF-gamma-producing cells were observed in all lymph node compartments, with a selective enrichment in germinal centers. The amount and distribution of IL-1 beta, IL-6-, and IL-2-producing cells in HIV lymph nodes were not different from those found in six HIV unrelated hyperplastic lymph nodes. In contrast, a higher level of INF-gamma production was observed in HIV-1 lymph nodes. The CD8+ cells that accumulate in germinal centers of HIV lymph nodes (and not in non-HIV germinal centers) were actively involved in this INF-gamma production. INF-gamma synthesizing cells were in direct contact with cells containing HIV core antigens and HIV RNA. Thus a high INF-gamma production may characterize anti-HIV T cell immune response, potentially contributing to control of viral spreading as well as to the development of follicle lysis.

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