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Research Article Free access | 10.1172/JCI114276

Rat renal epinephrine synthesis.

M G Ziegler, B Kennedy, and H Elayan

Department of Medicine, University of California, San Diego Medical Center 92103.

Find articles by Ziegler, M. in: JCI | PubMed | Google Scholar

Department of Medicine, University of California, San Diego Medical Center 92103.

Find articles by Kennedy, B. in: JCI | PubMed | Google Scholar

Department of Medicine, University of California, San Diego Medical Center 92103.

Find articles by Elayan, H. in: JCI | PubMed | Google Scholar

Published October 1, 1989 - More info

Published in Volume 84, Issue 4 on October 1, 1989
J Clin Invest. 1989;84(4):1130–1133. https://doi.org/10.1172/JCI114276.
© 1989 The American Society for Clinical Investigation
Published October 1, 1989 - Version history
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Abstract

Rats that underwent adrenal demedullation had a 93% decrease in plasma epinephrine (E) levels, but did not decrease their renal E. Even further treatment with 6-hydroxydopamine and reserpine failed to lower renal E levels. Similarly, urine E levels failed to decrease after adrenal demedullation and renal denervation. There is a renal E-synthesizing enzyme that differs from adrenal phenylethanolamine-N-methyltransferase (PNMT) in that it is only weakly inhibited by SKF 29661 and can synthesize epinine from dopamine, while adrenal PNMT does so poorly. When an adrenalectomized rat received intravenous [3H]methionine, its urine contained radioactivity that appeared to be [3H]E, with small amounts of [3H]epinine. However, after [3H]methionine was infused in the renal artery, the major product in urine appeared to be [3H]epinine, with a small amount of [3H]E. Adrenal demedullation induced renal E synthesis, but denervation returned the rate of renal E synthesis to control values. The combination of adrenal demedullation, 6-hydroxydopamine, and reserpine treatments increased renal E-forming activity to 350% of control. We conclude that appreciable portions of renal and urinary E are synthesized in the kidney by an enzyme distinct from PNMT. The enzyme is induced by some treatments that lower E and NE levels.

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