Advertisement
Research Article Free access | 10.1172/JCI114114
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Arnold, A. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Kim, H. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Gaz, R. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Eddy, R. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Fukushima, Y. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Byers, M. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Shows, T. in: JCI | PubMed | Google Scholar
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Find articles by Kronenberg, H. in: JCI | PubMed | Google Scholar
Published June 1, 1989 - More info
Parathyroid adenomas are common benign neoplasms for which no chromosomal defects have been described. We recently found two parathyroid adenomas bearing clonal restriction fragment abnormalities involving the PTH locus, and now show that in one of these tumors: (a) a DNA rearrangement occurred at the PTH locus; (b) the rearrangement separated the PTH gene's 5' flanking region from its coding exons, conceivably placing a newly adjacent gene under the influence of PTH regulatory elements; (c) the DNA that recombined with PTH normally maps to 11q13, the known chromosomal location of several oncogenes and the gene for multiple endocrine neoplasia type I; and (d) the rearrangement was a reciprocal, conservative recombination of the locus on 11q13 (Human Gene Mapping Library assignment D11S287) with PTH (on 11p15). These data provide molecular cytogenetic evidence for the clonal occurrence of a major chromosome 11 aberrancy in this benign parathyroid tumor. The D11S287 clone could prove useful in genetic linkage analyses, in determining precise 11q13 breakpoints in other neoplasms, and in identifying a gene on chromosome 11 that may participate in parathyroid tumor development.
Images.