Unequal decrease in bone density of lumbar spine and ultradistal radius in Colles' and vertebral fracture syndromes.

R Eastell; H W Wahner; W M O'Fallon; P C Amadio; L J Melton; B L Riggs

doi:10.1172/JCI113854

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Eastell, R. in: JCI | PubMed | Google Scholar

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Wahner, H. in: JCI | PubMed | Google Scholar

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by O'Fallon, W. in: JCI | PubMed | Google Scholar

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Amadio, P. in: JCI | PubMed | Google Scholar

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Melton, L. in: JCI | PubMed | Google Scholar

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

Find articles by Riggs, B. in: JCI | PubMed | Google Scholar

Published in Volume 83, Issue 1 on January 1, 1989
J Clin Invest. 1989;83(1):168–174. https://doi.org/10.1172/JCI113854.
© 1989 The American Society for Clinical Investigation

Published January 1, 1989 - Version history

We measured bone mineral density (BMD) at the lumbar spine (LS-BMD) and ultradistal radius (UDR-BMD) in 42 postmenopausal normal women and in 108 postmenopausal osteoporotic women (55 with vertebral fracture, 34 with Colles' fracture, and 19 with both fractures). By receiver operating characteristic analysis, LS-BMD was better than UDR-BMD (P less than 0.01) as an indicator of vertebral fracture; the converse was true for Colles' fracture (P less than 0.01). Although UDR-BMD and LS-BMD were lower in each of the three fracture groups than in controls (P less than 0.01), the pattern of bone loss differed (P less than 0.001, analysis of variance): with vertebral fracture, LS-BMD decreased relatively more than UDR-BMD; with Colles' fracture, UDR-BMD decreased relatively more than LS-BMD; and with both fractures, decreases in LS-BMD and UDR-BMD were similar. We conclude that both types of fracture are caused by excessive bone loss but the difference in bone loss at the two sites is a major factor in determining which will fracture.

Images.