Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

D Sorrentino; D Stump; B J Potter; R B Robinson; R White; C L Kiang; P D Berk

doi:10.1172/JCI113700

Department of Medicine, Mount Sinai School of Medicine, New York 10029.

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Department of Medicine, Mount Sinai School of Medicine, New York 10029.

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Department of Medicine, Mount Sinai School of Medicine, New York 10029.

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Department of Medicine, Mount Sinai School of Medicine, New York 10029.

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Department of Medicine, Mount Sinai School of Medicine, New York 10029.

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Published in Volume 82, Issue 3 on September 1, 1988
J Clin Invest. 1988;82(3):928–935. https://doi.org/10.1172/JCI113700.
© 1988 The American Society for Clinical Investigation

Published September 1, 1988 - Version history

Uptake of [3H]oleate by canine or rat cardiac myocytes is saturable, displays the countertransport phenomenon, and is inhibited by phloretin and trypsin. Cardiac myocytes contain a basic (pI approximately 9.1) 40-kD plasma membrane fatty acid binding protein (FABPPM) analogous to those recently isolated from liver, adipose tissue, and gut, unrelated to the 12-14-kD cytosolic FABP in these same tissues. An antibody to rat liver FABPPM selectively inhibits specific uptake of [3H]oleate by rat heart myocytes at 37 degrees C, but has no influence on nonspecific [3H]oleate uptake at 4 degrees C or on specific uptake of [3H]glucose. Uptake of long-chain free fatty acids by cardiac muscle cells, liver, and adipose tissue and absorption by gut epithelial cells is a facilitated process mediated by identical or closely related plasma membrane FABPs.

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Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

D Sorrentino, D Stump, B J Potter, R B Robinson, R White, C L Kiang, and P D Berk

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Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

D Sorrentino, D Stump, B J Potter, R B Robinson, R White, C L Kiang, and P D Berk

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