Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.

T Nosaka; H Ohno; S Doi; S Fukuhara; H Miwa; K Kita; S Shirakawa; T Honjo; M Hatanaka

doi:10.1172/JCI113526

Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Institute for Virus Research, Faculty of Medicine, Kyoto University, Japan.

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Published in Volume 81, Issue 6 on June 1, 1988
J Clin Invest. 1988;81(6):1824–1828. https://doi.org/10.1172/JCI113526.
© 1988 The American Society for Clinical Investigation

Published June 1, 1988 - Version history

Acute biphenotypic leukemia composed of lymphoblasts and myeloblasts developed in a patient with T lymphoblastic lymphoma (T-LBL) who had an anterior mediastinal mass. A novel myeloid cell line, termed TK-1, has been established from his peripheral blood after the leukemic conversion. The identical rearranged pattern of T cell receptor gamma-chain gene was observed among the DNAs derived from lymph node cells in the lymphoma phase, the myeloid cell line TK-1, and the subclones with different karyotypes (TK-1B and TK-1D), which showed that myeloid cells had been derived from the T-LBL of the same patient. This finding demonstrates that phenotypic conversion occurs in the clonally propagating tumor cells and suggests that some hematopoietic cells retain the capacity to adopt either lineage.

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Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.

T Nosaka, H Ohno, S Doi, S Fukuhara, H Miwa, K Kita, S Shirakawa, T Honjo, and M Hatanaka

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Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.

T Nosaka, H Ohno, S Doi, S Fukuhara, H Miwa, K Kita, S Shirakawa, T Honjo, and M Hatanaka

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