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Research Article Free access | 10.1172/JCI113484
Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Department of Microbiology, Medical University of South Carolina, Charleston 29425.
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Published May 1, 1988 - More info
The possible role of group specific component (Gc) (vitamin D-binding protein) in the clearance of cellular actin entering the circulation was examined with 125I-labeled Gc and actin injected into a rabbit model. Although filamentous F-actin is depolymerized primarily by plasma gelsolin, greater than or equal to 90% 125I-actin injected in either monomeric G- or F-form became complexed eventually with Gc (1:1 molar ratio). Clearance of Gc complexes was much faster (greater than 90% within 5 h) than that of native Gc (t1/2 = 17.2 h). Nephrectomy did not significantly alter the clearance of either Gc or actin. Since Gc complexes are dramatically increased in situations of tissue necrosis such as in fulminant hepatic failure, the current results suggest a crucial role for Gc in sequestration and clearance of released cellular actin.
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