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Research Article Free access | 10.1172/JCI113459

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

X M Sun and W Hsueh

Department of Pathology, Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614.

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Department of Pathology, Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614.

Find articles by Hsueh, W. in: PubMed | Google Scholar

Published May 1, 1988 - More info

Published in Volume 81, Issue 5 on May 1, 1988
J Clin Invest. 1988;81(5):1328–1331. https://doi.org/10.1172/JCI113459.
© 1988 The American Society for Clinical Investigation
Published May 1, 1988 - Version history
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Abstract

We have developed a rat model of ischemic bowel necrosis associated with shock by injection of platelet-activating factor (PAF) or a combination of PAF and endotoxin. Recent investigations have shown that tumor necrosis factor (TNF) also induces shock and necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF. The mechanism of TNF-induced bowel necrosis is unclear. In the present study, we have shown that (a) TNF caused PAF production in bowel tissue; (b) the effects of TNF and LPS on PAF production in the intestine are additive; (c) TNF and LPS are synergistic in inducing bowel necrosis; and (d) TNF-induced bowel necrosis is due to PAF release and can be prevented by pretreatment with PAF antagonists.

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