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Usage Information

Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.
D G Harrison, M L Armstrong, P C Freiman, D D Heistad
D G Harrison, M L Armstrong, P C Freiman, D D Heistad
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Research Article

Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

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Abstract

Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle.

Authors

D G Harrison, M L Armstrong, P C Freiman, D D Heistad

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Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 489 3
PDF 312 5
Scanned page 382 1
Citation downloads 203 0
Totals 1,386 9
Total Views 1,395
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ISSN: 0021-9738 (print), 1558-8238 (online)

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