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Research Article Free access | 10.1172/JCI113010

Vitamin D3 and cardiovascular function in rats.

R E Weishaar and R U Simpson

Find articles by Weishaar, R. in: JCI | PubMed | Google Scholar

Find articles by Simpson, R. in: JCI | PubMed | Google Scholar

Published June 1, 1987 - More info

Published in Volume 79, Issue 6 on June 1, 1987
J Clin Invest. 1987;79(6):1706–1712. https://doi.org/10.1172/JCI113010.
© 1987 The American Society for Clinical Investigation
Published June 1, 1987 - Version history
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Abstract

We have previously identified a receptor for 1,25-dihydroxyvitamin D3 in myocardial cells (Simpson, R.U. 1983. Circulation. 68:239.). To establish the relevance of this observation, we evaluated the role of the prohormone vitamin D3 in regulating cardiovascular function. In rats maintained on a vitamin D3-deficient diet for nine weeks, increases in systolic blood pressure (BP) and serum creatine phosphokinase (CPK) were observed. These increases coincided with a reduction of serum calcium from 10.3 to 5.6 mg/dl. However, while serum calcium remained depressed throughout the study, increases in BP and serum CPK were transient. After nine weeks of vitamin D3-depletion, but not after six weeks, ventricular and vascular muscle contractile function were also markedly enhanced. The increase in ventricular contractile function could not be prevented by maintaining serum calcium at 9.0 mg/dl during the period of D3-depletion. These observations suggest a primary role for the vitamin D3-endocrine system in regulating cardiovascular function.

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