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Research Article Free access | 10.1172/JCI112491

Infection of monocyte/macrophages by human T lymphotropic virus type III.

D D Ho, T R Rota, and M S Hirsch

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Published May 1, 1986 - More info

Published in Volume 77, Issue 5 on May 1, 1986
J Clin Invest. 1986;77(5):1712–1715. https://doi.org/10.1172/JCI112491.
© 1986 The American Society for Clinical Investigation
Published May 1, 1986 - Version history
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Abstract

Normal blood-derived monocyte/macrophages were found to be susceptible to infection in vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome. In addition, HTLV-III was recovered from monocyte/macrophages of patients infected with this virus. The above findings raise the possibility that HTLV-III-infected monocyte/macrophages may serve as a vehicle for the dissemination of virus to target organs and as a reservoir for viral persistence, as has been shown for other lentiviruses including visna virus and caprine arthritis encephalitis virus.

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