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Research Article Free access | 10.1172/JCI112450

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

L M Slater, P Sweet, M Stupecky, and S Gupta

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Published April 1, 1986 - More info

Published in Volume 77, Issue 4 on April 1, 1986
J Clin Invest. 1986;77(4):1405–1408. https://doi.org/10.1172/JCI112450.
© 1986 The American Society for Clinical Investigation
Published April 1, 1986 - Version history
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Abstract

The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.

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