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Research Article Free access | 10.1172/JCI112448

Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.

A A Rossini, J P Mordes, D L Greiner, K Nakano, M C Appel, and E S Handler

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Published April 1, 1986 - More info

Published in Volume 77, Issue 4 on April 1, 1986
J Clin Invest. 1986;77(4):1399–1401. https://doi.org/10.1172/JCI112448.
© 1986 The American Society for Clinical Investigation
Published April 1, 1986 - Version history
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Abstract

We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.

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