Usage Information

Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.
Y Shenker, R S Sider, E A Ostafin, R J Grekin
Y Shenker, R S Sider, E A Ostafin, R J Grekin
View: Text | PDF
Research Article

Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.

Abstract

Atrial natriuretic factor (ANF), a recently sequenced cardiac peptide, has been shown to have potent natriuretic, diuretic, and vasodilating effects in several species. We have developed a radioimmunoassay to measure the levels of immunoreactive ANF in human plasma. Plasma levels of ANF in healthy volunteers on a low sodium diet were 9.8 +/- 1.4 pmol/liter and increased to 21.9 +/- 3.0 on a high sodium diet. The levels of atrial natriuretic factor correlated directly with urinary sodium and inversely with plasma renin activity and plasma aldosterone levels. Patients with marked edema due to congestive heart failure had plasma levels of atrial natriuretic factor five times higher than normal (P less than 0.05), whereas patients with cirrhosis and edema had levels that were not different from normal. These results suggest that atrial natriuretic factor plays an important role in the adaptation to increased sodium intake.

Authors

Y Shenker, R S Sider, E A Ostafin, R J Grekin

×

Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 235 1
PDF 110 2
Scanned page 204 1
Citation downloads 128 0
Totals 677 4
Total Views 681
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement