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Research Article Free access | 10.1172/JCI110746

Cyclosporin A-treated guinea pig responder cells secrete a genetically restricted factor that suppresses the mixed leukocyte reaction.

G A DosReis and E M Shevach

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Published January 1, 1983 - More info

Published in Volume 71, Issue 1 on January 1, 1983
J Clin Invest. 1983;71(1):165–169. https://doi.org/10.1172/JCI110746.
© 1983 The American Society for Clinical Investigation
Published January 1, 1983 - Version history
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Abstract

Cyclosporin A (CY A) is a hydrophobic, undecapeptide, fungal metabolite with potent immunosuppressive effects on T lymphocyte-mediated immune responses. Suppressor T lymphocytes generated during a mixed leukocyte reaction (MLR) performed in the presence of CY A, release a factor that suppresses a primary MLR of responder T cells, which is derived from the same strain as the factor producer but lacks specificity for the stimulator cell. These results suggest a finely regulated pathway by which CY A may induce and maintain a permanent state of transplantation tolerance in vivo.

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