Null cell senescence and its potential significance to the immunobiology of aging.

J J Twomey; R J Luchi; N M Kouttab

doi:10.1172/JCI110594

Published July 1, 1982 - More info

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Abstract

The null cell compartments of human bone marrow and mouse spleen were arbitrarily divided into three subpopulations based upon the ability of cells to acquire T or B cell membrane markers when incubated with poly A:U or ubiquitin. There was an accumulation of T cell precursors with congenital absence of the thymus. In contrast, T cell precursors were reduced and there was an accumulation of uninduced null cells with old age. These observations suggest that there is an intrinsic defect of null cell differentiation with a drift towards more differentiated precursors in T cell differentiation with aging. This could result in a diminution in the range of responses by their progeny, mature T lymphocytes.

Null cell senescence and its potential significance to the immunobiology of aging.

J J Twomey, R J Luchi, and N M Kouttab

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Null cell senescence and its potential significance to the immunobiology of aging.

J J Twomey, R J Luchi, and N M Kouttab

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