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Research Article Free access | 10.1172/JCI110510

Instability of beta E-messenger RNA during erythroid cell maturation in hemoglobin E homozygotes.

J Traeger, P Winichagoon, and W G Wood

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Published April 1, 1982 - More info

Published in Volume 69, Issue 4 on April 1, 1982
J Clin Invest. 1982;69(4):1050–1053. https://doi.org/10.1172/JCI110510.
© 1982 The American Society for Clinical Investigation
Published April 1, 1982 - Version history
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Abstract

Hemoglobin E interacts with beta-thalassemia to produce a disorder of variable severity that is the most common form of symptomatic thalassemia in Southeast Asia. The beta E-globin gene acts as a mild thalassemia gene; there are low levels of beta E-messenger RNA (mRNA) in reticulocytes, and preliminary evidence had suggested that this might be due to instability of the beta E-mRNA. Analysis of beta E-mRNA levels in the nuclei and cytoplasm of bone marrow erythroblasts compared with reticulocytes has shown higher levels of beta E-mRNA in the former, providing direct evidence that this is the case.

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