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Research Article Free access | 10.1172/JCI110453

Safety and immunogenicity of high molecular weight polysaccharide vaccine from immunotype 1 Pseudomonas aeruginosa.

G B Pier

Find articles by Pier, G. in: JCI | PubMed | Google Scholar

Published February 1, 1982 - More info

Published in Volume 69, Issue 2 on February 1, 1982
J Clin Invest. 1982;69(2):303–308. https://doi.org/10.1172/JCI110453.
© 1982 The American Society for Clinical Investigation
Published February 1, 1982 - Version history
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Abstract

The safety and immunogenicity of a high molecular weight polysaccharide from immunotype 1 Pseudomonas aeruginosa were tested in a dose response fashion in adult volunteers. The vaccine lacked toxicity and pyrogenicity for experimental animals. Doses of 50, 75, 150, or 250 microgram were given to groups of individuals as a single dose subcutaneous injection. Doses of 150 and 250 microgram were associated with a significant rise in binding and opsonic antibody at 2 wk postimmunization. Titers remained unchanged for up to 6 mo. The vaccine was almost devoid of toxicity, eliciting no more than a slightly sore and tender arm at the site of injection. High molecular weight polysaccharide antigen appears to induce a good immune response following vaccination that is effective in mediating opsonophagocytic killing of live P. aeruginosa organisms.

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