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Citation Information: J Clin Invest. 1982;69(1):9-16. https://doi.org/10.1172/JCI110445.
Abstract
It has been shown that active immunization of rats with the capsular polysaccharide of Bacteroides fragilis protects these animals against abscess development following intraperitoneal challenge with this species. Passive transfer of hyperimmune globulin from immunized animals to nonimmune recipients provided protection against B. fragilis bacteremia in challenged animals, but did not confer protection against abscess development. On the other hand, adoptive transfer of spleen cells from immunized animals to nonimmunized recipients resulted in protection against abscesses following challenge with B. fragilis. These data suggested that a T cell-dependent immune response was involved in protection against abscess development after immunization with B. fragilis capsular antigen.
Authors
Andrew B. Onderdonk, Richard B. Markham, Dori F. Zaleznik, Ronald L. Cisneros, Dennis L. Kasper
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