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Research Article Free access | 10.1172/JCI110416

Responder cells in the human autologous mixed lymphocyte reaction.

J S Smolen, T A Luger, T M Chused, and A D Steinberg

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Published December 1, 1981 - More info

Published in Volume 68, Issue 6 on December 1, 1981
J Clin Invest. 1981;68(6):1601–1604. https://doi.org/10.1172/JCI110416.
© 1981 The American Society for Clinical Investigation
Published December 1, 1981 - Version history
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Abstract

Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells demonstrated substantial proliferation. These studies suggest that T8+ cells recognize signals from autologous non-T cells, but require an additional factor for the subsequent proliferative response. Since this stimulus can be provided by T4+ cells, the AMLR appears to constitute an inducer circuit. Different defects in this circuit may be responsible for the common abnormality of the AMLR in different diseases.

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