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Research Article Free access | 10.1172/JCI110334
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032
Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032
Find articles by Mundy, G. in: PubMed | Google Scholar
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032
Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032
Find articles by Demartino, S. in: PubMed | Google Scholar
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032
Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032
Find articles by Rowe, D. in: PubMed | Google Scholar
Published October 1, 1981 - More info
Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.
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