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Research Article Free access | 10.1172/JCI110334

Collagen and Collagen-derived Fragments Are Chemotactic for Tumor Cells

Gregory R. Mundy, Sandra Demartino, and David W. Rowe

Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284

Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032

Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032

Find articles by Mundy, G. in: PubMed | Google Scholar

Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284

Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032

Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032

Find articles by Demartino, S. in: PubMed | Google Scholar

Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284

Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032

Department of Pediatrics, University of Connecticut Health Center, Farmington, Connecticut 06032

Find articles by Rowe, D. in: PubMed | Google Scholar

Published October 1, 1981 - More info

Published in Volume 68, Issue 4 on October 1, 1981
J Clin Invest. 1981;68(4):1102–1105. https://doi.org/10.1172/JCI110334.
© 1981 The American Society for Clinical Investigation
Published October 1, 1981 - Version history
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Abstract

Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.

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