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Research Article Free access | 10.1172/JCI110248
Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461
Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461
Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris
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Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461
Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461
Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris
Find articles by Raventos-Suarez, C. in: JCI | PubMed | Google Scholar
Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461
Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461
Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris
Find articles by Fabry, M. in: JCI | PubMed | Google Scholar
Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461
Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461
Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris
Find articles by Tanowitz, H. in: JCI | PubMed | Google Scholar
Published July 1, 1981 - More info
HbE is a β-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.
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