Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI110248

Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes

Ronald L. Nagel, Carmen Raventos-Suarez, Mary E. Fabry, and Herbert Tanowitz

Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461

Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461

Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris

Find articles by Nagel, R. in: PubMed | Google Scholar

Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461

Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461

Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris

Find articles by Raventos-Suarez, C. in: PubMed | Google Scholar

Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461

Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461

Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris

Find articles by Fabry, M. in: PubMed | Google Scholar

Department of Medicine, Division of Experimental Hematology, Albert Einstein College of Medicine, Bronx, New York 10461

Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461

Service de Medicine Interne and Institut de Pathologie Moleculaire, CHU Cochin, Paris

Find articles by Tanowitz, H. in: PubMed | Google Scholar

Published July 1, 1981 - More info

Published in Volume 68, Issue 1 on July 1, 1981
J Clin Invest. 1981;68(1):303–305. https://doi.org/10.1172/JCI110248.
© 1981 The American Society for Clinical Investigation
Published July 1, 1981 - Version history
View PDF
Abstract

HbE is a β-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 303
page 303
icon of scanned page 304
page 304
icon of scanned page 305
page 305
Version history
  • Version 1 (July 1, 1981): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts