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Usage Information

Potentiation of Opsonization and Phagocytosis of Streptococcus pyogenes following Growth in the Presence of Clindamycin
Curtis G. Gemmell, … , Lewis Wannamaker, Paul G. Quie
Curtis G. Gemmell, … , Lewis Wannamaker, Paul G. Quie
Published May 1, 1981
Citation Information: J Clin Invest. 1981;67(5):1249-1256. https://doi.org/10.1172/JCI110152.
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Research Article

Potentiation of Opsonization and Phagocytosis of Streptococcus pyogenes following Growth in the Presence of Clindamycin

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Abstract

Streptococcus pyogenes, bearing M-protein on its surface, resists opsonization by normal human serum and subsequent phagocytosis by human polymorphonuclear leukocytes. Previous studies have shown that M-protein positive organisms are poorly opsonized by the alternate pathway of complement. In an attempt to define further the role of the surface components of S. pyogenes in this process, we examined the ability of clindamycin, an antibiotic that inhibits protein biosynthesis, to alter bacterial opsonization.

Authors

Curtis G. Gemmell, Phillip K. Peterson, David Schmeling, Youngki Kim, John Mathews, Lewis Wannamaker, Paul G. Quie

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 343 12
PDF 68 31
Figure 0 11
Scanned page 353 9
Citation downloads 70 0
Totals 834 63
Total Views 897
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