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Research Article Free access | 10.1172/JCI110124

Tolerance to the humoral and hemodynamic effects of caffeine in man.

D Robertson, D Wade, R Workman, R L Woosley, and J A Oates

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Published April 1, 1981 - More info

Published in Volume 67, Issue 4 on April 1, 1981
J Clin Invest. 1981;67(4):1111–1117. https://doi.org/10.1172/JCI110124.
© 1981 The American Society for Clinical Investigation
Published April 1, 1981 - Version history
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Abstract

Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.

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