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Immunoreactive β-Endorphin and Adrenocorticotropin in Human Cerebrospinal Fluid
Kazuwa Nakao, Shogo Oki, Issey Tanaka, Kazuko Horii, Yoshikatsu Nakai, Tomoo Furui, Masanori Fukushima, Akio Kuwayama, Naoki Kageyama, Hiroo Imura
Kazuwa Nakao, Shogo Oki, Issey Tanaka, Kazuko Horii, Yoshikatsu Nakai, Tomoo Furui, Masanori Fukushima, Akio Kuwayama, Naoki Kageyama, Hiroo Imura
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Research Article

Immunoreactive β-Endorphin and Adrenocorticotropin in Human Cerebrospinal Fluid

Abstract

To elucidate the significance of β-endorphin in human cerebrospinal fluid (CSF), CSF levels of β-endorphin-like immunoreactivity (β-EP-LI) in various diseases were determined by a specific radioimmunoassay and compared with simultaneously determined ACTH-like immunoreactivity (ACTH-LI) levels in CSF. CSF β-EP-LI and ACTH-LI in the control group, consisting of 5 normal subjects and 19 patients with nonendocrine diseases, were 22.2±1.3 and 14.6±0.4 fmol/ml, respectively. CSF levels of these peptides in patients with schizophrenia (n = 19) and acromegaly (n = 10) were not significantly different from those in the control group. Patients with Cushing's disease (n = 7) had significantly lower CSF β-EP-LI and ACTH-LI levels than those in the control group. Four of them showed a parallel increase in CSF β-EP-LI and CSF ACTH-LI levels after the complete removal of pituitary microadenomas (P < 0.05).

Authors

Kazuwa Nakao, Shogo Oki, Issey Tanaka, Kazuko Horii, Yoshikatsu Nakai, Tomoo Furui, Masanori Fukushima, Akio Kuwayama, Naoki Kageyama, Hiroo Imura

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