Sustained Oscillations of Insulin, Glucagon, and Somatostatin from the Isolated Canine Pancreas during Exposure to a Constant Glucose Concentration

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Abstract

Canine pancreata were perfused in vitro to examine whether hormone cycles could be demonstrated without hepatic or central nervous influence. Insulin, glucagon, and somatostatin demonstrated regular sustained cyclic secretion from the in vitro canine pancreas. Oscillations were noted for over 200 min during the infusion of a constant glucose concentration. Insulin demonstrated a 10-min period with a range of 8-12 min/cycle. Somatostatin had a 10-min period with a range of 8-11 min. Glucagon had a period of 8.6 min with range of 6-10 min. These periods do not allow glucagon to be consistently 90° out of phase with insulin and somatostatin.

Authors

John I. Stagner, Ellis Samols, Gordon C. Weir