Advertisement

Research Article Free access | 10.1172/JCI109747

Origin of platelet-derived growth factor in megakaryocytes in guinea pigs.

A Chernoff, R F Levine, and D S Goodman

Find articles by Chernoff, A. in: JCI | PubMed | Google Scholar

Find articles by Levine, R. in: JCI | PubMed | Google Scholar

Find articles by Goodman, D. in: JCI | PubMed | Google Scholar

Published April 1, 1980 - More info

Published in Volume 65, Issue 4 on April 1, 1980
J Clin Invest. 1980;65(4):926–930. https://doi.org/10.1172/JCI109747.
© 1980 The American Society for Clinical Investigation
Published April 1, 1980 - Version history
View PDF
Abstract

Growth factor activity, as determined by the stimulation of [3H]thymidine incorporation into the DNA of quiescent 3T3 cells in culture, was found in lysates of guinea pig platelets and megakaryocytes. Quantitative dilution studies demonstrated that, of the cells present in the guinea pig bone marrow, only the megakaryocyte possessed quantitatively significant growth factor activity. The amount of activity present in one megakaryocyte was equivalent to that present in 1,000-5,000 platelets, a value approximately comparable to the number of platelets shed from a single megakaryocyte. It is suggested that guinea pig platelet-derived growth factor has its origin in the megakaryocyte.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (April 1, 1980): No description
Advertisement
Advertisement