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Usage Information

Carbenicillin and Penicillin G Inhibit Platelet Function In Vitro by Impairing the Interaction of Agonists with the Platelet Surface
Sanford J. Shattil, Joel S. Bennett, Margaret McDonough, Judy Turnbull
Sanford J. Shattil, Joel S. Bennett, Margaret McDonough, Judy Turnbull
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Research Article

Carbenicillin and Penicillin G Inhibit Platelet Function In Vitro by Impairing the Interaction of Agonists with the Platelet Surface

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Abstract

Carbenicillin or penicillin G administered in large doses can cause a bleeding diathesis as a result of platelet dysfunction. These antibiotics also inhibit platelet aggregation in vitro, although several-fold larger concentrations of drug are required to demonstrate this effect. We wondered whether these antibiotics might impair platelet function by interfering with the initial step of platelet activation: the binding of agonists to their specific receptors on the platelet surface.

Authors

Sanford J. Shattil, Joel S. Bennett, Margaret McDonough, Judy Turnbull

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Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 264 41
PDF 95 9
Scanned page 245 1
Citation downloads 62 0
Totals 666 51
Total Views 717
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