Renal Adaptation to a Low Phosphate Diet in Rats: BLOCKADE BY ACTINOMYCIN D

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Abstract

The major renal adaptive changes in response to selective dietary phosphate restriction are a marked reduction in urinary excretion of phosphate and an increased urinary excretion of calcium; at the cellular level, there is selective increase in renal cortical brush border membrane phosphate uptake and increase in specific activity of alkaline phosphatase. In the present study we examined whether these functional and biochemical adaptive changes could be blocked by drugs known to inhibit protein synthesis.

Authors

Sudhir V. Shah, Stephen A. Kempson, Thomas E. Northrup, Thomas P. Dousa