Advertisement

Research Article Free access | 10.1172/JCI109320

Human C4-binding protein. Association with immune complexes in vitro and in vivo.

J Scharfstein, E B Correa, G R Gallo, and V Nussenzweig

Find articles by Scharfstein, J. in: PubMed | Google Scholar

Find articles by Correa, E. in: PubMed | Google Scholar

Find articles by Gallo, G. in: PubMed | Google Scholar

Find articles by Nussenzweig, V. in: PubMed | Google Scholar

Published March 1, 1979 - More info

Published in Volume 63, Issue 3 on March 1, 1979
J Clin Invest. 1979;63(3):437–442. https://doi.org/10.1172/JCI109320.
© 1979 The American Society for Clinical Investigation
Published March 1, 1979 - Version history
View PDF
Abstract

C4-binding protein (bp), a glycoprotein with specific binding affinity for the activated form of C4 (C4b), has recently been isolated from human serum and partially characterized. This report demonstrates that C4-bp is incorporated into soluble immune complexes after complement activation in vitro. The reaction requires Ca++ ions and the presence of C4 in serum. Immunopathological studies of various forms of glomerulonephritis revealed intense C4-bp deposition in glomeruli from patients with immune-complex type of pathogenesis. C4-bp deposition was in close correlation with that of C4. These observations, together with the in vitro association of C4-bp to immune complexes, support the notion that the deposits in glomeruli represent the local accumulation of immune complexes.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (March 1, 1979): No description
Advertisement
Advertisement