Endogenous Angiotensin Stimulation of Vasopressin in the Newborn Lamb

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Abstract

The effect of furosemide on plasma renin, vasopressin (AVP), and aldosterone concentrations was studied in 10 control and 6 nephrectomized lambs during the 1st 2 wk of life. In a separate study in 10 newborn lambs, 1-sarcosine-8-alanine-angiotensin II (saralasin acetate, 5 μg/kg per min) was infused alone for 40 min, after which furosemide 2 mg/kg i.v. was injected in association with continuing saralasin acetate infusion.

Authors

Sharon R. Siegel, Richard E. Weitzman, Delbert A. Fisher