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Research Article Free access | 10.1172/JCI109282

Demonstration of a specific neutrophil receptor for a cell-derived chemotactic factor.

I Spilberg and J Mehta

Find articles by Spilberg, I. in: PubMed | Google Scholar

Find articles by Mehta, J. in: PubMed | Google Scholar

Published January 1, 1979 - More info

Published in Volume 63, Issue 1 on January 1, 1979
J Clin Invest. 1979;63(1):85–88. https://doi.org/10.1172/JCI109282.
© 1979 The American Society for Clinical Investigation
Published January 1, 1979 - Version history
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Abstract

The crystal-induced chemotactic factor, a cell-derived chemoattractant for neutrophils, binds specifically to a site on human neutrophils but not to erythrocytes or lymphocytes, suggesting a relationship between the presence of specific binding sites on the neutrophils and the ability to be chemotactically activated. The Scatchard analysis revealed an equilibrium dissociation constant at 37 degrees C of 0.446 micrometer and the presence of approximately equal to 6.44 x 10(5) binding sites for 125I-crystal-induced chemotactic factor per cell. Binding was not displaced by the synthetic chemotactic factors F-Met-Leu-Phe and Gly-His-Gly or by complement-activated plasma providing evidence of the specificity of the receptor.

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