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Usage Information

Differences in Oxygen Metabolism of Phagocytosing Monocytes and Neutrophils
Michael Reiss, Dirk Roos
Michael Reiss, Dirk Roos
Published February 1, 1978
Citation Information: J Clin Invest. 1978;61(2):480-488. https://doi.org/10.1172/JCI108959.
View: Text | PDF
Research Article

Differences in Oxygen Metabolism of Phagocytosing Monocytes and Neutrophils

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Abstract

The oxidative metabolism of monocytes and polymorphonuclear leukocytes from human peripheral blood was studied in resting and phagocytosing cells. Monocytes, like neutrophils, showed an increase in oxygen consumption during phagocytosis with a concurrent release of superoxide anions and hydrogen peroxide. Both oxygen products are highly reactive agents with potential bactericidal activity. Neutrophils consumed two and a half times as much oxygen, generated about twice as much superoxide, and released five times as much hydrogen peroxide as monocytes did. Monocytes generated superoxide and hydrogen peroxide at equivalent rates.

Authors

Michael Reiss, Dirk Roos

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