Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.

P Arnaud; R M Galbraith; W P Faulk

doi:10.1172/JCI108906

Published December 1, 1977 - More info

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Abstract

Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.

Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.

P Arnaud, R M Galbraith, and W P Faulk

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Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.

P Arnaud, R M Galbraith, and W P Faulk

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