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Usage Information

The Maladaptive Renal Response to Secondary Hypocapnia during Chronic HCl Acidosis in the Dog
Nicolaos E. Madias, William B. Schwartz, Jordan J. Cohen
Nicolaos E. Madias, William B. Schwartz, Jordan J. Cohen
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Research Article

The Maladaptive Renal Response to Secondary Hypocapnia during Chronic HCl Acidosis in the Dog

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Abstract

It has generally been thought that homeostatic mechanisms of renal origin are responsible for minimizing the alkalemia produced by chronic hypocapnia. Recent observations from this laboratory have demonstrated, however, that the decrement in [HCO−3], which “protects” extracellular pH in normal dogs, is simply the by-product of a nonspecific effect of Paco2 on renal hydrogen ion secretion; chronic primary hypocapnia produces virtually the same decrement in plasma [HCO−3] in dogs with chronic HCl acidosis as in normal dogs (Δ[HCO−3]/ΔPaco2 = 0.5), with the result that plasma [H+] in animals with severe acidosis rises rather than falls during superimposed forced hyperventilation.

Authors

Nicolaos E. Madias, William B. Schwartz, Jordan J. Cohen

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
Text version 326 13
PDF 120 10
Scanned page 290 9
Citation downloads 152 0
Totals 888 32
Total Views 920
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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