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Modulatory effects on immunoglobulin synthesis and secretion by lymphocytes from immunodeficient patients.
S A Schwartz, … , L Shou, R A Good
S A Schwartz, … , L Shou, R A Good
Published June 1, 1977
Citation Information: J Clin Invest. 1977;59(6):1176-1187. https://doi.org/10.1172/JCI108742.
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Research Article

Modulatory effects on immunoglobulin synthesis and secretion by lymphocytes from immunodeficient patients.

Abstract

Incubation of peripheral lymphocytes (PBL) from normal donors with pokeweek mitogen (PWM) induced terminal differentiation by B lymphocytes to immunoglobulin (Ig) synthesizing and secreting plasma cells. B cells from hypogammaglobulinemic patients with different primary immunodeficiencies failed to undergo functional differentiation after similar treatment with PWM. Co-cultures of BL from normal donors and hypogammaglobulinemic patients often resulted in deviations, both positive and negative, from expected levels of PWM-stimulated intracellular Ig biosynthesis. Suppression of B-cell differentiation was manifested by PBL from patients with several different primary immunodeficiencies, including infantile sex-linked agammaglobulinemia. Immunoregulatory activities were noted to vary with the normal donor used in co-culture experiments and with time. Cell populations that were active in influencing B-cell differentiation to functional plasma cells did not have an appreciable modulatory effect on T-lymphocyte responses to mitogens. These observations may provide a functional subclassifications for immunoregulatory cells in man.

Authors

S A Schwartz, Y S Choi, L Shou, R A Good

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