Usage Information

Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.
K J Johnson, … , T P Anderson, P A Ward
K J Johnson, … , T P Anderson, P A Ward
Published May 1, 1977
Citation Information: J Clin Invest. 1977;59(5):951-958. https://doi.org/10.1172/JCI108717.
View: Text | PDF
Research Article

Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.

Abstract

Small amounts (10(-10) mol) of purified human chemotactic factor inactivator (CFI) suppress leukocytic infiltration, permeability changes, and hemorrhage associated with acute immune complex-induced injury in rats. The reversed passive dermal Arthus reaction and acute immune complex-induced alveolitis in rats have served as the model systems of inflammation. The mechanism of inhibition does not appear to relate to interference with formation and deposition of immune complexes, or with fixation of complement in vitro or iv vivo. Human CFI inhibits in vitro the chemotactic activity generated in complement-activated rat serum. The inhibitory effects of human CFI are not seen if it is first heat inactivated. The data provide the first direct support for the conclusion that CFI has anti-inflammatory activity.

Authors

K J Johnson, T P Anderson, P A Ward

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 99 0
PDF 329 15
Scanned page 232 2
Citation downloads 61 0
Totals 721 17
Total Views 738
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement