Advertisement

Research Article Free access | 10.1172/JCI108674

Induction of arthritis by purified cell-derived chemotactic factor: role of chemotaxis and vascular permeability.

I Spilberg, D Rosenberg, and B Mandell

Find articles by Spilberg, I. in: PubMed | Google Scholar

Find articles by Rosenberg, D. in: PubMed | Google Scholar

Find articles by Mandell, B. in: PubMed | Google Scholar

Published March 1, 1977 - More info

Published in Volume 59, Issue 3 on March 1, 1977
J Clin Invest. 1977;59(3):582–585. https://doi.org/10.1172/JCI108674.
© 1977 The American Society for Clinical Investigation
Published March 1, 1977 - Version history
View PDF
Abstract

The injection of monosidium urate-induced chemotactic factor into the joint cavities of rabbits induces an acute inflammatory response that resembles the one produced by monosodium urate crystals. The leukocyte accumulation induced by the factor was not accompanied by a measurable increase in vascular permeability as measured by appearance of 125I-albumin in the joint cavity. When histamine was injected into the joints, a marked increase in vascular permeability but no leukocytosis above control levels was observed. The above results suggest that the cell-derived factor is primarily responsible for the accumulation of cells seen in the acute inflammation induced by monosodium urate crystals.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (March 1, 1977): No description
Advertisement
Advertisement