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Concise Publication Free access | 10.1172/JCI107815

Evaluation of Leukocyte Chemotaxis In Vitro in Thermally Injured Patients

Glenn D. Warden, Arthur D. Mason Jr., and Basil A. Pruitt Jr.

United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

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United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

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United States Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas 78234

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Published October 1, 1974 - More info

Published in Volume 54, Issue 4 on October 1, 1974
J Clin Invest. 1974;54(4):1001–1004. https://doi.org/10.1172/JCI107815.
© 1974 The American Society for Clinical Investigation
Published October 1, 1974 - Version history
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Abstract

Leukocyte chemotaxis in vitro was studied by a modification of the Boyden technic in 46 thermally injured patients. All patients demonstrated a decrease in leukocyte migration through a Nuclepore filter toward a standard casein-serum chemotactic agent. Leukocyte chemotaxis was inversely correlated with burn size during the first 72 h after injury. After 72 h, leukocyte chemotaxis directly correlated with clinical status and was highly predictive for ultimate mortality. Since mortality was largely due to infection, these findings suggest that suppression of leukocyte chemotaxis may explain the susceptibility to opportunistic infection in thermally injured patients.

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