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Research Article Free access | 10.1172/JCI107776
Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
Anesthesia Laboratory, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02115
Harvard Medical School, Boston, Massachusetts 02115
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Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
Anesthesia Laboratory, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02115
Harvard Medical School, Boston, Massachusetts 02115
Find articles by Cohn, P. in: PubMed | Google Scholar
Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
Anesthesia Laboratory, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02115
Harvard Medical School, Boston, Massachusetts 02115
Find articles by Klein, M. in: PubMed | Google Scholar
Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
Anesthesia Laboratory, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02115
Harvard Medical School, Boston, Massachusetts 02115
Find articles by Laver, M. in: PubMed | Google Scholar
Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
Anesthesia Laboratory, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02115
Harvard Medical School, Boston, Massachusetts 02115
Find articles by Gorlin, R. in: PubMed | Google Scholar
Published August 1, 1974 - More info
Oxyhemoglobin dissociation (OHD) curves were performed on whole blood (WB) from 20 patients with anginal pain, normal hemodynamics, and normal coronary arteries, as demonstrated by selective coronary cinearteriography. OHD curves in 19 of 20 patients, from zero to full saturation, were nearly identical to those in normal control subjects with values for P50 (Po2 at 50% saturation and pH 7.4) of 26.7±1.5 (mean±SD of the mean) torr (mm Hg) and red blood cell (RBC) levels of 2,3-diphosphoglyceric acid (2, 3-DPG) of 0.72±0.10 (mean±SD of the mean) M/M hemoglobin (Hb). Normal values for nonsmoking adults were: P50, 26.6±1.4 (mean±SD of the mean) torr: and RBC 2,3-DPG, 0.81±0.09 (mean±SD of the mean) M/M Hb. Mean levels of carbon monoxide were normal at 0.14±0.01 (mean±SEM) ml/100 ml WB in 10 patients who were nonsmokers and 0.45±0.15 (mean±SEM) ml/100 ml WB in 10 smokers. In one patient, a heavy smoker with markedly elevated blood carbon monoxide levels, an abnormal leftward shift of the OHD curve was observed. This was corrected after discontinuation of smoking. In utilizing these methods, we could not detect consistent abnormalities of Hb affinity for oxygen at rest in the patients studied, which suggests that a defect in oxygen transport at rest is an unlikely explanation for the symptoms of chest pain in patients with the anginal syndrome and normal coronary arteriograms.
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