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Concise Publication Free access | 10.1172/JCI107746

Lung Tissue Elastin Composition in Newborn Infants with the Respiratory Distress Syndrome and Other Diseases

Hugh E. Evans, Stephen Keller, and Ines Mandl

Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032

Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York 10032

Find articles by Evans, H. in: PubMed | Google Scholar

Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032

Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York 10032

Find articles by Keller, S. in: PubMed | Google Scholar

Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York 10032

Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York 10032

Find articles by Mandl, I. in: PubMed | Google Scholar

Published July 1, 1974 - More info

Published in Volume 54, Issue 1 on July 1, 1974
J Clin Invest. 1974;54(1):213–217. https://doi.org/10.1172/JCI107746.
© 1974 The American Society for Clinical Investigation
Published July 1, 1974 - Version history
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Abstract

Amino acid analysis of human fetal lung elastin was undertaken in 49 instances of live-born neonates, ranging from 380 g to full term, and in 3 abortuses of 12-14 wk gestation. The data suggest that formation of the cross-linking agents, desmosine and isodesmosine, occurs early, between 14 and 22 wk. The ratio of neutral to charged amino acids remains low until the 36th wk when it attains adult levels. The composition of elastin was independent of sex and duration of survival. In three neonatal pulmonary diseases (respiratory distress syndrome, atelectasis, and hemorrhage) ratios were significantly lower than those found in nondiseased lungs. This may be a reflection of immaturity or may be a predisposing factor in neonatal lung disease. The latter hypothesis is attractive and receives indirect support from the association of a more polar elastin with other diseases, including adult emphysema and atheromatous aortic change.

Our finding of relatively high polarity in elastin from human fetal lung is consistent with previous observations in a variety of fetal organs of other species.

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