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Research Article Free access | 10.1172/JCI107600

Augmentation of prolactin secretion by estrogen in hypogonadal women.

S S Yen, Y Ehara, and T M Siler

Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California 92037, USA.

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Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California 92037, USA.

Find articles by Ehara, Y. in: JCI | PubMed | Google Scholar

Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California 92037, USA.

Find articles by Siler, T. in: JCI | PubMed | Google Scholar

Published February 1, 1974 - More info

Published in Volume 53, Issue 2 on February 1, 1974
J Clin Invest. 1974;53(2):652–655. https://doi.org/10.1172/JCI107600.
© 1974 The American Society for Clinical Investigation
Published February 1, 1974 - Version history
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Abstract

The effect of estrogen on prolactin (PRL) release and gonadotropin suppression was assessed in six experiments performed on four hypogonadal women. Ethinyl estradiol at a dose of 1 microgram/kg per day induced a significant elevation of serum PRL levels within the 1st wk of treatment. There was a further rise until a plateau was reached in about 3-4 wk to levels of more than 3 times the initial concentration. This was accompanied by a pattern of increased episodic fluctuation. The corresponding serum luteinizing hormone and follicle-stimulating hormone fell progressively during the study period. These data indicate that a positive feedback relationship between estrogen and PRL release exists in humans.

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